Today, Irene Gabashvili, PhD., MEBO Research Scientific Director and Principal Investigator of the MEBO Clinical Trial, "Microbial Basis of Systemic Malodor and PATM Conditions (PATM), NCT03582826 (2018-2020), published a paper on the findings of this study in the JMIR Dermatology Publications.

A total of 112 individuals from 22 countries consented to participate, of which 84 fully participated in the study.

The study referenced in the article, "Cutaneous Bacteria in the Gut Microbiome as Biomarkers of Systemic Malodor and People Are Allergic to Me (PATM) Conditions: Insights From a Virtually Conducted Clinical Trial," suggests that body and/or breath odor was increased when the levels of bacteria previously associated with skin body odor were significantly elevated in the gut samples of the study. Gut samples indicated an elevated "combination of species from Anaerococcus, Corynebacterium, Campylobacter, and Propionibacterium genera..."

About half of the participants had previously tested for trimethylaminuria (TMAU), and about half of those tested were diagnosed with the disorder.

A total of 112 individuals from 22 countries consented to participate, of which 84 fully participated in the study. About half of the participants had previously tested for trimethylaminuria (TMAU), and about half of those tested were diagnosed with the disorder. “Of the 84 study volunteers, 41 (49%; 41/78, 53% of MEBO/PATM cohort) tested for the odor-producing disorder TMAU, with 13 positives for primary TMAU and 8 for secondary TMAU, a nongenetic form arising from dysbiosis in the gut bacteria.”

Dr. Gabashvili discusses her finding in her Aurametrix site, Olfactics and Olfactory Diagnostics: New Paper Reveals Insights into Bacteria that Live...: What do MEBO (metabolic body odor), PATM ("People are Allergic to ME" condition) and TMAU (trimethylaminuria) have in common...

Irene gives us the following page in her Aurametrix Blog, which shows the last 3-4 digits of MEBO participants' IDs. This way they can recognize themselves in the "vector field" of results. These 22 participants had at least one pair of "better" and "worse" MEBO/PATM symptoms. The paper has more figures with results of the remaining participants, analyzed in several different ways.

Quotes from the paper:

Conclusions: ...Our work paves the way for the development of cost-effective diagnostics of MEBO and PATM conditions based on an at-home stool test...
Another implication of this work is that individuals with a high abundance of cutaneous malodor bacteria in the gut might benefit from reducing levels of these bacteria. We note that one of the common causes of both halitosis and axillar odor is a zinc deficiency. Zinc oxide is known to decrease populations of bacteria discussed in this work when applied externally [41], attenuating self-perceived malodor. Zinc also contributes to the reduction of halitosis [42]. However, not all people with MEBO and PATM are zinc deficient, and it is important to retain certain levels of cutaneous odor-producing bacteria in the body, as they prevent some skin, ear, and respiratory infections

REFERENCE:

Gabashvili IS
Cutaneous Bacteria in the Gut Microbiome as Biomarkers of Systemic Malodor and People Are Allergic to Me (PATM) Conditions:
Insights From a Virtually Conducted Clinical Trial

JMIR Dermatol 2020;3(1):e10508

URL: https://derma.jmir.org/2020/1/e10508

doi:10.2196/10508

Trial Registration:ClinicalTrials.gov NCT03582826

International Registered Report Identifier (IRRID):RR2-10.1101/2020.08.21.20179242

MEBO (metabolic body odor)

PATM ("People are Allergic to ME" condition)

TMAU (trimethylaminuria)

ACKNOWLEDGMENTS:

We are most grateful to MEBO's Scientific Director, Irene Gabashvili, PhD., Principal Investigator of this study, for offering her pro-bono professional through the years for this and all other MEBO Research clinical trials.Our profound appreciation to uBiome for the research grant they awarded MEBO for this study as well as to their representative, Melissa Agnello for processing the samples. We appreciate the professional psychological guidance that Crissan Rosalia, MEBO Mental Health Director, Health Psychologist, MSc., with articles she has written for our MEBO community around the world. These can be found in the MEBO MENTAL HEALTH BLOG.

María

María de la Torre
Founder and Executive Director

A Public Charity
www.meboresearch.org
MEBO's Blog (English)
El Blog de MEBO (español)

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Are PATM & odor conditions related?

The following is my opinion and personal observations as the Founder and Executive Director of the Charity, MEBO Research, Inc. My opinion is based on my online communications with thousands of malodor/PATM sufferers from around the world these past 10+ years, hundreds of whom I have met in person in the United States and England since 2008.

It is not uncommon in the MEBO community that sufferers who have been diagnosed with TMAU, those who have an odor condition other than TMAU, and those who think they do not emit odor at all, claim to have PATM. For example, I once met a sufferer in person who really did not emit odor that I could detect. However, I experienced allergic reactions whenever I got close to her and my allergy symptoms improved when I moved away from her. She claimed that some people told her she has had odor from time to time, but I did not perceive it at the time.

DO PATM SUFFERERS SMELL?

A TMAU research scientist who has worked in his lab with the odorous chemical, trimethylaminuria (TMA) who claims to have an allergic reaction every time he is exposed to TMA. He says that everyone in the lab detects a very strong odor that engulfs the whole lab when he opens the bottle containing TMA, but he does not smell anything. Instead, he says that his eyes begin to tear and he experiences an allergic reaction.

It appears that the same is true regarding compounds found in the environment that some people may not smell, but may react to them in an allergic manner. For example, many airlines have opted to not serve peanuts during a flight because some passengers have had life-threatening severe allergic reactions to peanuts, even when they are not eating them. Yet, not everyone can smell the peanuts and not everyone experience an allergic reaction to them. See post, "Do they smell me or not?"

Many of the participants of the MEBO Gut Microbiome Study have odor also claim that people are allergic to them. See U.S. study sponsored by uBiome and registered with ClinicalTrials.gov: "Clinical Trial, Microbial Basis of Systemic Malodor and PATM Conditions (PATM)". Some of these sufferers have been diagnosed with TMAU and others have had negative results in their TMAU test, indicating that they do not have TMAU. Most claim that they have odor, at least intermittently, but not all. Some sufferers are parents of small children who experience allergic reactions to the sufferer. The children's allergic symptoms only go away when they physically separate from the sufferer. How sad is that!

The question of the century is "which chemical(s) in the bodies are people around us reacting in an allergic manner to?" It could be any chemical that is not normally found at high levels inside the human body, not sufficiently (completely) metabolized in the liver, or it could be an abnormally elevated levels of some normal compounds due to overproduction of them by gut bacteria. Frequently, the source of these compounds come from the all. Other times, we pick up the compounds from the environment through the breath or exposure to the skin from the air or buildings sufferers come in contact with, etc, as Yoshika Sekine, PhD, Professor at Tokai University, Japan, President, Society of Indoor Environment, Japan, tells us in his PATM research paper.

Click on icon to see paper (English translation)
Original in Japanese

Each PATM sufferer may have different compounds (different from other PATM sufferers) in their bodies that other people react to in an allergic manner. On the other hand, there are people who are never allergic to anything while others have allergic reactions.

All these factors make it extremely difficult to diagnose the exact cause of PATM for each sufferer individually. This is the reason we hope that scientists like Professor Sekine would pursue further research into PATM in order to design therapeutic tests for this problem. Meanwhile, we can only work with some of the current tests already developed, like the uBiome Gut Explorer test, the genetic or biochemical TMAU test, or all the tests gastroenterologist can do to determine the health of the digestive tract, how well the kidneys are wfunctioning, hormonal balance/health, etc.

The best recommendation to PATM sufferers is to eat natural and organic foods that do not have preservatives, or have been fed hormones or antibiotics. The less the food is processed, the better. Organic foods are best. Eliminate sodas and other drinks consisting of a concoction of chemicals with no nutritional benefit whatsoever. Those chemicals can irritate the digestive tract and may be very difficult, or impossible, for a deficient metabolism to handle.

In other words, whether people are having allergic reactions or not is not the question to focus on in an effort to find a solution, in my opinion. The question to focus on is to try to find the root of the problem, which is which specific compound(s) inside the body that come out through the pores and breath are people reacting to in an allergic manner? Why are they inside the body to begin with? What damage have they done to the body, i.e., digestive tract, skin rashes, kidneys, etc.? Until this is determined and until which foods and/or environmental conditions are determined to cause an abnormal build-up of these compounds in the body, and consequently triggering PATM, a sufferer will not be able to control the condition. So much more research is desperately needed!

María

María de la Torre
Founder and Executive Director

A Public Charity
maria.delatorre@meboresearch.com
www.meboresearch.org
MEBO's Blog (English)
El Blog de MEBO (español)

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Friday Night TMAU, PATM, Body Odor Interview #2

Friday night Podcasts
PATM / BODY ODOR SUFFERER

I want to interview TMAU, PATM, or Fecal Body Odor sufferers.

email: skivac3@gmail.com

So I just want to alert people about trying to do interviews on this channel.Maybe I shouldn't really call it interviews, but I want you to tell your life story about how you got this disorder and how you are coping at the moment"

Interview on PATM

Our skin is very moist. Since one of the skin's "job" is to expel toxins and impurities from the body, these toxins are released through the moisture/perspiration of the skin. With exercise, there is a great deal of perspiration, so the toxins are expelled from the body. However, if you still have alot more toxins inside your body, you need to help the skin continue to get it all out with more exercise and/or sauna, and then wash it away with a bath/shower.

In addition, it's essential to identify the source of the toxin buildup. What causes your body to have these odorous toxins? It's just as important to help your cleansing organs expel these toxins(skin thru perspiration, lungs through the breath, kidneys by drinking plenty of fluids) as it is to stop the source of these toxins to begin with.

Do they smell me or not?
https://www.meboblog.com/2011/01/do-they-smell-me-or-not.html

María

$818 million deal new path for CRISPR therapies

Click on item to see article

For years sufferers of uncontrollable odor conditions including, but not limited to TMAU, and those who suffer from those around them developing allergic reactions to elevated compounds emitted from their bodies (PATM), have hoped to someday have access to gene therapies and alternative therapies other than antibiotics to get to the root of the problem. The up to $818 million deal between Locus Biosciences and Janssen Pharmaceuticals (a division of Johnson & Johnson) addresses the possibility of materializing this dream.

In addition to developing effective genetic therapies for various diseases, the union of these two companies will also continue with research and develop the use of bacteriophages designed to target bacterial infection. This is just the beginning and still in the clinical trial phases, but at least it is well funded and the goal of these companies is to ultimately "manufacture and commercialize CRISPR-Cas3-enhanced products targeting bacterial pathogens for the potential treatment..."

The up to $818 million deal between Locus Biosciences and Janssen Pharmaceuticals (a division of Johnson & Johnson) that was announced yesterday points toward a new path for CRISPR gene editing technologies and (potentially) the whole field of microbiome-targeted therapies...

While the Cas9 CRISPR technologies can edit targeted DNA — either deleting specific genetic material or replacing it with different genetic code — Cas3 simply removes DNA strains. “Its purpose is the destruction of invading DNA,” says Locus chief executive, Paul Garofolo...
Locus is already commercializing a version of its technology with bacteriophages designed to target e coli bacteria to treat urinary tract infections. The company is on target to begin its first clinical trials in the third quarter of the year...

The focus on bacterial infection and removing harmful bacteria while ensuring that the rest of a patient’s microbiome is intact is a huge step forward for treating diseases that scientists believe could be linked to bacterial health in a body, according to Garofolo.
techcrunch.com

María

María de la Torre
Founder and Executive Director

A Public Charity
maria.delatorre@meboresearch.com
www.meboresearch.org
MEBO's Blog (English)
El Blog de MEBO (español)
MEBO Brasil - Blog (Portuguese)

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PATM Research Paper 2018

Click on icon to see paper (English translation)
Original in Japanese

PATM Research Paper

Click on icon to see
Power Point Presentation

Yoshika Sekine, PhD, Professor at Tokai University, Japan, President, Society of Indoor Environment, Japan, along with a team of scientists carried out research on PATM Syndrome . We are highly thankful to all of them for giving their precious time to researching and exploring PATM Syndrome.

On April 14, 2018, the Founder and Executive Director of MEBO Research, Maria de la Torre, asked Prof. Sekine to help present his work to raise awareness throughout the globe from the MEBO Annual Conference & Meetup held in Savannah, Georgia this year.Our most sincere thanks to Prof. Yoshika for creating a PowerPoint presentation and providing us with his research paper on the study . We have shared this in many forums through platform of MEBO . The research paper was in Japanese language so MEBO arranged to translate the PATM Syndrome research paper in English language with the help of Director of Community Outreach and Strategy , Mehmet Ali.

Again Sir, thanks you very much for working on this syndrome. Please do not hesitate to contact me if you believe there is anything I can do to support your work.

Research paper is property of Prof. Yoshika and their co-authors and is translated and presented in the MEBO sites with their expressed consent.  We want to raise awareness throughout the globe about PATM syndrome using this effort of Prof and his team of scientists. I hope this information is helpful to other scientists and inspires future research into PATM...

To qualify as participant MEBO/uBiome Study

Click on icon

The Principal Investigator of the uBiome grant-funded MEBO research study, "Dynamics of the Gut Microbiota in Idiopathic Malodor Production", Irene Gabashvili, PhD., MEBO Scientific Director, has written a post about the study in her company's blog, AURAMETRIX. This post includes MEBO/PATM Life Quality Test, "MEBO means metabolic body odor and it includes systemic body odor, bad breath and episodes of malodor NOT related to hygiene or flatulence. PATM denotes "People Allergic To Me" condition. The survey asks about symptoms In the past 24 hours or past few days, up to a week before taking this test."

We are starting pre-screening our candidates to find qualified participants, based on prior test results and ability to accurately report information.

Participants will be asked to submit their samples to uBiome on as different days in terms of their well-being/mood/symptoms as possible. MEBO is a condition of ups and downs. One day you may be completely odor-free, the next day you may have severe odor episodes - called flares. Our participants will be asked to submit their first sample if they felt they experienced symptoms, or had a day or two different from average. Study participants will be asked to submit responses to our questionnaire about those days.
We will privately follow up with suggestions to improve their wellbeing.

Our new Life-quality Test questionnaire will provide a measure for severity of Metabolic Breath and Body Odor and PATM symptoms.

Anyone who may possibly be interested in participating in this study can get a better idea of what it entails and is welcome to take the first version of this Life Quality Test.

María
María de la Torre
Founder and Executive Director

A Public Charity
maria.delatorre@meboresearch.com
www.meboresearch.org
MEBO's Blog (English)
El Blog de MEBO (español)
MEBO Brasil - Blog (Portuguese)

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The MEBO Wholly Volunteer Staff

OUR VOLUNTEER STAFF

The whole MEBO Volunteer staff is highly thankful to the countless efforts of their Executive Officer, Maria de la Torre, for the establishment and operations of the international MEBO Organization for past 10 Years. You are the pride of whole MEBO community throughout the world.

FOUNDER AND EXECUTIVE DIRECTOR

Maria de la Torre
Founder and Executive Director, MEBO Research

maria.delatorre@meboresearch.org

SCIENTIFIC DIRECTOR AND CONSULTANTS

The MEBO community around the world is most appreciative of our Scientific Director and many MEBO Consultants, who have been steadfastly supportive and dedicated to the MEBO Mission throughout these past 10 years. We are very proud of them.

Dr. Irene Gabashvilli
Principal Investigator and Scientific Director of MEBO US

irene.gabashvili@meboresearch.org
irene@aurametrix.com

Dr. Elizabeth Shephard
Consultant and Principal Investigator of MEBO UK

info@meboresearch.org

Nigel Manning

Principal Scientist ofSheffield Children’s Hospital

info@meboresearch.org

Dr. Hazen

MEBO Consultant

info@meboresearch.org

Public Relation Director

Karen James
Director ofPublic Relations UK
karen.james@meboresearch.org

Glenna Gonalez

Director ofPublic Relations US

glenna.gonzalez@meboresearch.org

Managing Director

Mike

MEBO Managing Director

mike@meboresearch.org

User Experience and Technology Director

Jason

User Experience and Technology Director

info@meboresearch.org

Community Outreach and Strategy Director

Mehmet Ali

Community Outreach and Strategy U.K. Director

m.ali@meboresearch.org
muhammadali28121998@gmail.com

Community Outreach Director

Akiya Browning

U.S. DirectorCommunity Outreach

akiya.browning@meboresearch.org

Mental Health Director

Crissan Rosalia

Mental Health Director of MEBO

c.rosalia@meboresearch.org
takechartge@re-charge.org

Mexican Affairs Director

Maria Cristina Sanchez Lopez

Director of Mexican Affairs of MEBO

maria.cristina@meboresearch.org

Director of Peruvian Affairs

Maria Claudia

Director of Peruvian Affairs of MEBO

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Director of Brazilian Affairs

Thiego

Director of Brazillian Affairs MEBO

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